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In moderation while taking Diflucan. Fluconazole works best if it is taken at the same time each day. Fluconazole has been used in the fungal infection Cryptococcus. Fluconazole appears to be a safe and effective treatment for cutaneous leishmaniasis. Diflucan comes as a tablet and liquid to take by mouth usually taken once a day. Fluconazole is a triazole antifungal agent that can be administered orally or parenterally. Diflucan comes with a patient information leaflet. Do not stop taking Diflucan without talking to your doctor.